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Many species are infected by lentiviruses, which are characteristically responsible for long-duration illnesses with a long incubation period.Lentiviruses are transmitted as single-stranded, positive-sense, enveloped RNA viruses.In most cases, HIV is a sexually transmitted infection and occurs by contact with or transfer of blood, pre-ejaculate, semen, and vaginal fluids.Non-sexual transmission can occur from an infected mother to her infant through breast milk.

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Upon entry into the target cell, the viral RNA genome is converted (reverse transcribed) into double-stranded DNA by a virally encoded enzyme, reverse transcriptase, that is transported along with the viral genome in the virus particle.

The resulting viral DNA is then imported into the cell nucleus and integrated into the cellular DNA by a virally encoded enzyme, integrase, and host co-factors.

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